The Royal Danish Academy of Sciences and Letters with support from The Novo Nordisk Foundation are proud to announce the fourteenth Royal Academy Nobel Laureate Lecture.
After the lecture the audience is invited to a reception. Attending the lecture as well as the reception is free of charge but registration below is necessary.
Professor John Gurdon, Wellcome Trust/Cancer Research UK Gurdon Institute, recieved the 2012 Nobel Prize in Physiology or Medicine.
Nuclear reprogramming and prospects for cell replacement in humans.
Over half a century ago it was found possible to derive a normal adult frog from an intestine cell. In more recent times nuclear transfer has been achieved in several kinds of mammals and to some extent in humans. iPS has transformed the practicability of using nuclear reprogramming for cell replacement therapy. It is therefore possible, in principle, to produce new eye cells and other kinds of adult cells, from a small piece of skin of the same individual. This lecture will review the procedures involved as what can be said about the mechanisms involved. It will also discuss likely future possibilities as well as ethical and legal concerns in this field.
Professor at Biotech Research and Innovation, University of Copenhagen, Anja Groth writes about the Laureate:
Sir John Gurdon was awarded the Nobel prize in Physiology or Medicine in 2012 together with Professor Shinya Yamanaka for ‘the discovery that mature cells can be reprogrammed to be pluripotent’. This represents a paradigm shift in our understanding of cellular differentiation and the plasticity of the mature cell, which has introduced a new research area with exciting opportunity for disease treatment.
In 1962, Sir John Gurdon discovered that the nucleus of a specialized mature cell can be fully reverted to an immature state that in turn can give rise to a functional organism. Since then, Gurdon’s continued investigations of nuclear reprogramming has provided pivotal knowledge about the barriers that restrict cell fate and the means whereby these barriers can be overcome. With his great work, continued scientific curiosity and relentless exploration of mechanisms that underlie epigenetic cell memory, Gurdon is a great source of inspiration for us all.